Compulsive Behavior Side Effects?

More often than not we hear or read about me discussing taking personal responsibility and being personally held accountable for our words and actions. This post won’t be any different. I found it humorous that I was sent the link to the below information and shortly after reading it I heard a damn commercial for the same thing. Odd what we hear on the radio @ 02:30 am while driving my happy ass to work. Anyone, I would assume, who watches television or listens to the radio has seen or heard at least one Ambilify commercial. True or not? Having a son who suffers from mild bipolar disorder we have been bombarded with samples and prescription answers which will somehow magically transform behavior. I tell you from my personal experience, we don’t use my son for a testing ground so big pharmaceuticals can make their billions at the cost of my son’s mental well-being. So, when I saw this bullshit about the lawsuit towards the makers of Ambilify I merely smiled to myself because we all know there is not one single perfect medication with no side effects. While my son has never taken Ambilify, we did research it extensively, just as we have done with many others.

But why are we here right now? But why did I choose to write about it right now? It’s simple, this is another example of people who cannot be responsible for their own actions. It’s about people who blame someone else for their own behavior because they acted without self control. It’s because people want the quick fix. It’s about people who choose to not read the small print or they choose to ignore the small print. Yes, I find this lawsuit as being fucking stupid because people made bad choices but don’t want to take responsibility for their own decisions. But then we know in our society nobody is forced to be held accountable, it’s always somebody else at fault. Bullshit! If we fuck up we just sue someone because we can profit from our lack of responsibility. Or have we forgot that coffee from a fast food joint is extremely hot and will burn the fuck out out your crotch if you spill it? People are dumbasses. Let this be yet just one more example.

The following information was originally found here and provided by a leading contributor to The Scorpion Army. I don’t have any express or otherwise permissions to copy this story from the above linked website or to use it on my blog as part of a post which includes my personal opinion. Hopefully they understand I do not support the lawsuit efforts but do not hold the above website responsible for posting this story. In the end, if they wish that I remove it in part or completely it will happen swiftly and immediately. The two pictures were borrowed from the internet using Google. Remember, I neither gain or loose anything by sharing the following information, it’s just being shared because I found it truly interesting.

Abilify has been linked to compulsive behavior side effects, such as pathological gambling, binge eating and hypersexuality. These behaviors are thought to be triggered by the neurotransmitters dopamine and serotonin.

One of the most popular treatments for a variety of mental disorders like depression, schizophrenia and bipolar disorder,  makes billions for Bristol-Myers Squibb and the Otsuka Pharmaceutical Company. It was the top-selling drug in the U.S. in 2013 with sales of over $6.4 billion. The drug works by either increasing or decreasing dopamine or serotonin in the brain when there is an imbalance, and this makes it useful for a variety of approved and unapproved uses.

However, the drug is also linked to disturbing compulsive behavior side effects that can wreak havoc on the lives of patients and their families.

Among these side effects, compulsive or pathological gambling can be financially crippling, and it can destroy lives. People in the grip of compulsive behaviors will do anything they can to continue the chosen activity, even if it means ignoring the rest of their lives and withdrawing from friends and family.

This side effect in particular may lead to lawsuits against Bristol-Myers and Otsuka America, claiming the companies did not properly warn patients and doctors of this serious side effect.

In addition, reports of other side effects include compulsive eating, shopping and even sex addiction.

How Abilify Causes Compulsive Behavior

While doctors aren’t exactly sure how Abilify (aripiprazole) works, they believe it acts on receptors in the brain for chemicals that regulate mood and behavior. These chemicals are neurotransmitters called dopamine and serotonin.

When the dopamine system is stimulated in response to a particular activity, people will feel a high from it or a feeling of pleasure. This reward system normally ensures that we continue to eat and do other things we need to do to survive. In people with mental disorders, these systems are stimulated excessively, or not enough.

Researchers think Abilify may over-stimulate dopamine reward receptors in the brain – called dopamine 3 (D3) receptors – and trigger compulsive behavior.

Compulsive Gambling

Several case studies focused on a connection between aripiprazole and compulsive behavior, also called pathological behavior, especially in the case of gambling. One French study published in 2013 by Gaboriau, et al., examined several people who checked into a clinic because of their compulsive gambling behaviors. Study authors looked at eight individuals who took Abilify as part of ongoing medical treatment. Researchers found the drug caused seven of the eight patients to lose control of their gambling habits.

After discontinuing the drug or greatly reducing the dose, patients regained control of their compulsive behaviors, researchers wrote.

Another 2011 case study by Cohen, et al. found similar results in patients treated for schizophrenia. No patients in this study had a history of pathological gambling. Soon after taking the drug, they began gambling uncontrollably.

Similarly, a 2011 British study conducted by the National Problem Gambling Clinic found a relationship between Abilify and the drive to gamble in some patients. Doctors described one case in which a patient took the antipsychotic and “was preoccupied with thoughts of gambling and his gambling activity became both impulsive and involved extensive planning in obtaining funds to gamble, including the use of crime.”

Another patient said gambling became “a reason to live” after he took the drug.

In all cases, gambling problems resolved after discontinuing Abilify and switching to another drug.

Why Do Doctors Have Differing Opinions

After a grueling fucking twenty minute conversation with my VA healthcare professional, a person whom I can barely understand much less say her name or even try to spell it, I made the choice to speak with her civilian counterpart in the sector of private medicine. I was solely looking for confirmation of the information I was given in regards to my diabetes and how the peripheral neuropathy in my feet is getting worse over time instead of better. I currently take Pregabalin (which is used to relieve neuropathic pain from damaged nerves that can occur in your arms, hands, fingers, legs, feet, or toes if you have diabetes. Pregabalin is in a class of medications called anticonvulsants. It works by decreasing the number of pain signals that are sent out by damaged nerves in the body.) after being prescribed two others which made me sick to my stomach and didn’t work for me personally. As of lately, the Pregabalin seems to have just stopped working with a considerable increase in the pain in my feet. I called for consultation to see if I had other options. But, as she read straight out of the “VA doctor to patient book of protocol bullshit”, she explained that this treatment prescribed by her IS working for me and any idea it isn’t working is just my imagination.

She don’t even know about my imagination first of all and I have spent less than fifteen minutes total in the three times I have been in her presence so how in the hell can she claim such bullshit. Yes, I understand they are busy doctoring and shit but the dirt under my fingernails has more bedside manner than she could ever hope to have. So, I phoned my civilian doctor, who tells me that no treatment is 100% foolproof and our bodies get nonreactive to most medication we take on a regular basis. No shit! How do I fix it? I hate the awkward silence that happens after an unexpected question or answer because I wonder if I crossed that all to visible line we’re never supposed to cross. Anyway. What my point? The conversation that I had with each doctor got me thinking about the below article I read not to long ago and I just wanted to explain WHY I was sharing it out of the blue like I am. It also made me think of the above sketch, because I do see doctors as “angels” and the serpents they battle within when confronted with doing the right thing or doing only how they are taught. No, I don’t think all doctors are quacks selling snake-oil remedies, but many get tied up in being a doctor before being a human being. I would love to hear your opinions if y’all don’t mind taking a minute.

Why Health Professionals Become Quacks

William T. Jarvis, Ph.D.

It is especially disappointing when an individual trained in the health sciences turns to promoting quackery. Friends and colleagues often wonder how this can happen. Some reasons appear to be:

Boredom

Daily practice can become humdrum. Pseudoscientific ideas can be exciting. The late Carl Sagan believed that the qualities that make pseudoscience appealing are the same that make scientific enterprises so fascinating. He said, “I make a distinction between those who perpetuate and promote borderline belief systems and those who accept them. The latter are often taken by the novelty of the systems, and the feeling of insight and grandeur they provide” [1] Sagan lamented the fact that so many are willing to settle for pseudoscience when true science offers so much to those willing to work at it.

Low professional esteem

Nonphysicians who don’t believe their professions is sufficiently appreciated sometimes compensate by making extravagant claims. Dental renegades have said “All diseases can be seen in a patient’s mouth.” Fringe podiatrists may claim to be able to judge health entirely by examining the feet. Iridologists point to the eye, chiropractors the spine, auriculotherapists the ear, Registered Nurses an alleged “human energy field,” and so on. Even physicians are not immune from raising their personal status by pretension. By claiming to cure cancer or to reverse heart disease without bypass surgery, general physicians can elevate themselves above the highly trained specialists in oncology or cardiology. By claiming to heal diseases that doctors cannot, faith healers advance above physicians on the social status chart (physicians are normally at the top of the chart while preachers have been slipping in modern times). Psychologists, physicians, actors, or others who become health gurus often become darlings of the popular press.

Paranormal tendencies

Many health systems are actually hygienic religions with deeply-held, emotionally significant beliefs about the nature of reality, salvation, and proper lifestyles. Vegetarianism, chiropractic, naturopathy, homeopathy, energy medicine, therapeutic touch, crystal healing, and many more are rooted in vitalism, which has been defined as “a doctrine that the functions of a living organism are due to a vital principle [“life force”] distinct from physicochemical forces” and “the theory that biological activities are directed by a supernatural force.” [2,3] Vitalists are not just nonscientific, they are antiscientific because they abhor the reductionism, materialism, and mechanistic causal processes of science. They prefer subjective experience to objective testing, and place intuitiveness above reason and logic. Vitalism is linked to the concept of an immortal human soul, which also links it to religious ideologies [4].

Paranoid mental state

Some people are prone to seeing conspiracies everywhere. Such people may readily believe that fluoridation is a conspiracy to poison America, that AIDS was invented and spread to destroy Africans or homosexuals, and that organized medicine is withholding the cure for cancer. Whereas individuals who complain about conspiracies directed toward themselves are likely to be regarded as mentally ill, those who perceive them as directed against a nation, culture, or way of life may seem more rational. Perceiving their political passions are unselfish and patriotic intensifies their feelings of righteousness and moral indignation [5]. Many such people belong to the world of American fascism, Holocaust deniers, tax rebels, the radical militia movement, and other anti-government extremists who would eliminate the FDA and other regulatory agencies that help protect consumers from health fraud. Liberty Lobby’s newspaper The Spotlight champions such causes and also promotes quack cancer cures and attacks fluoridation.

Reality shock

Everyone is vulnerable to death anxiety. Health personnel who regularly deal with terminally ill patients must make psychological adjustments. Some are simply not up to it. Investigation of quack cancer clinics have found physicians, nurses, and others who became disillusioned with standard care because of the harsh realities of the side effects or acknowledged limitations of proven therapies.

Beliefs encroachment

Science is limited to dealing with observable, measurable, and repeatable phenomena. Beliefs that transcend science fall into the realms of philosophy and religion. Some people allow such beliefs to encroach upon their practices. While one may exercise religious or philosophical values of compassion, generosity, mercy and integrity (which is the foundation of the scientific method’s search for objective truth), it is not appropriate for a health professional to permit metaphysical (supernatural) notions to displace or distort scientific diagnostic, prescriptive or therapeutic procedures. Individuals who wish to work in the area of religious belief should pursue a different career.

The profit motive

Quackery can be extremely lucrative. Claiming to have a “better mousetrap” can cause the world to beat a path to one’s door. Greed can motivate entrepreneurial practitioners to set ethical principles aside.

The prophet motive

Just as Old Testament prophets called for conversion and repentance, doctors have to “convert” patients away from smoking, obesity, stress, alcohol and other indulgences [6]. As prognosticators, doctors foretell what is going to happen if patients don’t change their way of life. The prophet role provides power over people. Some doctors consciously avoid it. They encourage patients to be self-reliant rather than dependent, but in doing so they may fail to meet important emotional needs. Quacks, on the other hand, revel in, encourage, and exploit this power. Egomania is commonly found among quacks. They enjoy the adulation and discipleship their pretense of superiority evokes.

Psychopathic tendencies

Studies of the psychopathic personality provide insight into the psychodynamics of quackery. Dr. Robert Hare who investigated for more than twenty years, states, “You find psychopaths in all professions. . . the shyster lawyer, the physician always on the verge of losing his license, the businessman with a string of deals where his partners always lost out.” [7] Hare describes psychopaths as lacking a capacity to feel compassion or pangs of conscience, and as exhibiting glibness, superficial charm, grandiosity, pathological lying, conning/manipulative behavior, lack of guilt, proneness to boredom, lack of empathy, and other traits often seen in quacks. According to Hare, such people suffer from a cognitive defect that prevents them from experiencing sympathy or remorse.

The conversion phenomenon

The “brainwashing” that North Koreans used on American prisoners of war involved stress to the point that it produced protective inhibition and dysfunction. In some cases, positive conditioning causes the victim to love what he had previously hated, and vice-versa; and in other cases, the brain stops computing critically the impressions received. Many individuals who become quacks undergo a midlife crisis, painful divorce, life-threatening disease, or another severely stressful experience. The conversion theory is supported by a study of why physicians had taken up “holistic” practices. By far the greatest reason given (51.7%) was “spiritual or religious experiences.” [8]

Many people ”including far too many health professionals, law enforcement officials, and judges’ exhibit a cavalier attitude toward quackery. Although most reject the idea that quackery is “worth a try” for a sick person [9], it is important to reinforce and mobilize those who understand quackery’s harmful potential.

References

Reid WH and others. Unmasking the Psychopath. New York: W.W. Norton and Company, 1986.Webster’s New Collegiate Dictionary.Dorland’s Illustrated Medical Dictionary, 25th Edition. Philadelphia: WB Saunders Co. 1974.Sarton G. A History of Science, Volume I. New York: W.W. Norton & Company, 1952, p.497.Hofstadter R. The Paranoid Style in American Politics and Other Essays. New York: Alfred A. Knopf, 1966.Dominian J. Doctor as prophet. British Medical Journal 287:1925-1927, 1983.Goleman D. Brain defect tied to utter amorality of the psychopath. The New York Times, July 7, 1987.Goldstein MS, Jaffe DT, Sutherland C. Physicians at a holistic medical conference: Who and why?” Health Values 10:3-13, Sept/Oct 1986.Morris LA, Gregory J D, Klimberg R. Focusing an advertising campaign to combat medical quackery. Journal of Pharmaceutical Marketing and Management 2:(1):83-96, 1987.

About the Author

William Jarvis, Ph.D, is a retired professor of public health and preventive medicine at the Loma Linda University School of Medicine. Jarvis is founder and president of the National Council Against Health Care Fraud and is co-author of a textbook, Consumer Health: A Guide to Intelligent Decisions, 7th Edition.

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Struggling With Dueling Personalities

As my 18 year old daughter pushes through her second semester in college to become a RN she has come face to face with the fact that there are many psychology and sociology classes to attend. She knows the human brain really fascinates me and she knows I have my own out of the normal box way of thinking, meaning I question everything. Because of my age and personal experiences I tend to have a jaded opinion about my fellow human beings. It makes me hard to talk to at times because I don’t want to talk about “how” I got where I stand today because much of my personal past is still unknown to even the closest people in my life. Simply put, there are things I choose not to discuss, its just the way it is.

Anyway, she had a paper to write about personality disorders versus mental disorders. She didn’t know the “line” between them is often blurred, often confused, often misidentified, and very often a person gets mislabeled. Now, she is familiar with bipolar disorder since her brother struggles daily with it. She had to learn the “disorder” in order to live in peace with her brother in a comfortable manner for both of them. She thought she had this paper nailed until she asked me to review it. Its not that she had it all wrong, because she didn’t. But, because the terms are confusing, it makes the information available confusing. Jokingly, I told her that the specialists who study these and other disorders make it difficult to learn for job security, which is both true and false in every conceivable way. So, I gave her my interpretation, whether it helped or not we will have to see when she gets her grade. Below is how I see it.

Sometimes people confuse two mental disorders, only one of which could be referred to as “common” within the population which is bipolar disorder and then schizophrenia. This confusion has largely resulted from the common use of some of these names in popular media, and as short-hand by people referring to someone who is grappling with a mental health issue. The disorders, however, have little in common other than the fact that many who have them are still stigmatized by society.

Bipolar disorder is a fairly common mental disorder compared with the other two disorders. Bipolar disorder is also well-understood and readily treated by a combination of medications and psychotherapy. It is characterized by alternating moods of mania and depression, both of which usually last weeks or even months in most people who have the disorder. People who are manic have a high energy level and often irrational beliefs about the amount of work they can accomplish in a short amount of time. They sometimes take on a million different projects at once and finish none of them. Some people with mania talk at a faster rate and seem to the people around them to be constantly in motion.

After a manic mood, a person with bipolar disorder will often “crash” into a depressive mood, which is characterized by sadness, lethargy, and by a feeling that there’s not much point in doing anything. Problems with sleep occur during both types of mood. Bipolar disorder affects both men and women equally and can be first diagnosed throughout a person’s life.

Bipolar disorder can be challenging to treat because, while a person will take an antidepressant medication to help alleviate a depressed mood, they are less likely to remain on the medications which help reign in the manic mood. Those medications tend to make a person feel “like a zombie” or “emotionless,” which are feelings most people wouldn’t want to experience. So many people with bipolar disorder find it difficult to maintain treatment while in their manic phase. However, most people with bipolar disorder function relatively well in normal society and manage to cope with their mood swings, even if they don’t always keep on their prescribed medications.

However, schizophrenia is less common than bipolar disorder and is usually first diagnosed in a person’s late teens or early to late 20’s. More men than women receive a diagnosis of schizophrenia, which is characterized by having both hallucinations and delusions. Hallucinations are seeing or hearing things that aren’t there. Delusions are the belief in something that isn’t true. People who have delusions will continue with their delusions even when shown evidence that contradicts the delusion. That’s because, like hallucinations, delusions are “irrational”, the opposite of logic and reason. Since reason doesn’t apply to someone who has a schizophrenic delusion, arguing with it logically gets a person nowhere.

Schizophrenia is also challenging to treat mainly because people with this disorder don’t function as well in society and have difficulty maintaining the treatment regimen. Such treatment usually involves medications and psychotherapy, but can also involve a day program for people who have more severe or treatment-resistant forms of the disorder.

Because of the nature of the symptoms of schizophrenia, people with this disorder often find it difficult to interact with others, and conduct normal life activities, such as holding down a job. Many people with schizophrenia go off of treatment (sometimes, for instance, because a hallucination may tell them to do so), and end up homeless, without friends or family, and sometimes end their life as a plausible solution.

All people suffer, period. No person wants or needs to be a “lab rat” in the discovery of what ails them mentally. But, society dictates we label and judge others based on our opinions, ignorance, lack of understanding, and the pure lack of compassion. I know what y’all are thinking, and yes I do judge people myself in regards to stupidity and the utter lack of common sense. So, I do live the double standard in many ways, I ride that double edge sword like the evil bitch she is. Its one of many of my personal faults. I’m definitely not an expert on this topic, but in my defense I have read about and studied this topic for many, many years because the subject is very near and dear to me. Nor do I claim that what I have interpreted or formed my own opinion on is dead nuts accurate. As with all things, interpretation is the ultimate devil in the woodpile.

We can learn allot by paying attention and observing our fellow humans, but more often than not we choose to just ignore the people around us. We have become dependent on others to guide us in life for some fucked up reason. However, I do know two doctors, y’all know who you are, who take a different approach to medicine, they look at the person first, not the diagnosis. They take into consideration that we a people with feelings, emotions, and look at alternative ways to treat the various symptoms of life. I appreciate my two friends a great deal, one day I would like to shake the hands of Kris and Rexi because they have taken time out of their lives to include me into their lives. They are both amazing women in my opinion and anyone who has them in their daily lives are truly lucky.

Anyway, in closing, helping my daughter helps me more often than not because it gives me a chance to reevaluate the things I think I know well and opens my mind to the possibilities that there are other options. I get pretty set in my damn ways sometimes but my thirst for knowledge will never be quenched as long as I’m still breathing. My dad once told me, the summer he died, that people prey on the closed mind, they prey because the closed mind is that of a victim, and they begin with the upper hand because they know how defenseless a victim is. Is it true? I still challenge myself to this very day not to be a victim with a closed mind. Do you?

Spending The Entire Day Waiting

Yesterday I spent the entire day at the Michael E. DeBakey Veterans Affairs Medical Center in Houston waiting for assistance at the pharmacy. When I say all day what I really mean is I was in line for mandatory valet parking at 7:04 am, by line I mean there were already 64 vehicles ahead of me, for a service which doesn’t even start until 7:30 am. This is after a 55 minute drive from my house. But, before I begin my monologue about my personal frustrations with the VA Medical wait times or my personal complaints, my experience is minor compared to most others trying to get more critical treatment. In no way am I saying I have bigger problems, just I have my own problems. Regardless of what a person’s reason for visiting a VA Medical center, things should happen in a more timely manner than what it does currently.

My reason, and I had only one reason, for visiting the VA Medical center was a very clear and simple mission, to find out who and why my insulin changed. I would waste time explaining the significance to everyone but only a diabetic and doctors (most) would understand. Let’s just say we don’t change insulin for no reason at a whim. What started this quest was simple, Friday I got my new 30 day supply of insulin which was the wrong “brand” and the wrong dose. Names change so I did a little research and found what they sent me was wrong altogether. I called the pharmacy, and the short version is, I was told I must be mistaken and if a mistake was made it was because I ordered refills for the wrong insulin. Really? I’m that fucking stupid? I referred to my Rx # and so forth directly from the myhealth website and I was again told the mistake was all me. After hanging up I contacted my PCP in Conroe, spoke with her nurse, and was assured nothing had changed in my prescription details. Well, at that point in the day it way too late to drive into the VA so I made plans for Monday morning. Unfortunately those plans got scrapped and I was delayed until Tuesday. For your curiosity purposes I have included a screen capture from today to illustrate how vets can use this website to order and track prescriptions and yes this is my own personal list.

After driving, after waiting for mandatory valet parking, and after getting my number at the pharmacy, I sat there prepared to have a discussion with the pharmacist. I had my last vile, the vile they sent me, and the printed version of what you see below. So, I waited. after 2 1/2 hours my number came up so I got in line to wait another 20 minutes. Finally, when it was my turn to speak with a pharmacy technician, I was told that he could not help me with my problems and that I would need to take a different number so I could be consulted by the pharmacist. WTF? Again, I sat and waited in the sparsely populated waiting room of the pharmacy. Now, we are in lunch time so the slowness begins creeping to an almost halt. I’m hungry, but not hungry enough to leave and lose my place in line. Good thing I had brought a baggie full of spicy roasted almonds for a snack. Somewhere around 2:30 pm I was again alerted my number was up and got back in the line to wait behind the others whose numbers were called. Finally, the light at the end of the tunnel appears, I’m next. I was so close I could taste it.

The pharmacist very nicely asked what my problems were and how could he assist me. After explaining it all again to him he looked at me and told me any and all changes had to come directly from my PCP. Really? What changes did she make which changed not only my insulin but almost triples my dose? Of course, there ate no changes on record. The he pulled the “you must have ordered the wrong insulin when you did your refill request” bullshit. How in the hell can I do that? I have one fucking choice and that is what in the fuck I clicked. Here is the real kick in the balls, he tells me regardless of anything that is said that the current 30 day supply of insulin has already been verified, processed, and shipped which means he can not refill any more until July and if changes through my PCP happen then those will need to happen prior to that date. WTF are you smoking? If I am in need of this insulin immediately then I need to purchase it on my own. If I thought I would look good in prisoner orange I would have just ended his smart ass right then and there. FUCK I hate this fucking place!

And, by the way, one can not simply go to a civilian pharmacy and get insulin without a fucking prescription. I can, however, go on line and order it from a pharmacudicals supply in Canada with no prescription for a mere $260.10 plus express shipping. Yea, like that’s gonna fucking happen. Who knows what the fuck would be in that vile. As a result, my civilian PCP was nice enough to see me this morning. That only cost me $167.30 but he did give me a prescription for the correct insulin and the correct dosage. Which was generous of him, probably since I have been a patient of his for the last 15 years. So I got lucky, this time. At the pharmacy I had to pay the self-pay cost of $208.08 but now I have what I need for the next thirty days. I also am able to get in to see my VA PCP at the end of June so things hopefully work out and get back on track, hopefully.

No, I do not think I can ever get them to admit this whole thing was their mistake. I have come to a conclusion in the short time of dealing with the medical portion of the VA, they have to not have a soul or something to work there. I wonder how in the fuck they sleep at night. I do know, it is because they operate with no conscience. But, to be fair, I base this opinion solely on the people I have encountered myself. However, I have met ex-VA doctors, nurses, and technicians who say that they did not agree with how things worked but their hands were always tied when trying to make a positive difference. I can’t say I know what every veteran is going through and I know my problems are simple compared to most because my are Rx related. I would hate to see the state of my “health & wellbeing” if my only option was the VA. I am deeply sorry our Veterans must endure such bullshit as a course of their own survival, they truly deserve better, they deserve the best that is offered, and maybe with their asses in the news now the VA will clean their act up. I know, I know, wishful thinking.

Kermit The Frog Gets An Xray

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